Percutaneous absorption of 5 glycol ethers through human skin in vitro. Venier M, Adami G, Larese F, Maina G, Renzi N. Toxicol In Vitro. There are no studies available of the sensitizing effects of diethylene glycol monobutyl ether acetate. Diethylene glycol is an organic compound with the formula (HOCH2CH2)2O. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). Clean Air Act: CAS# 112-34-5 (listed as Glycol ethers (except for EGBE)) is listed as a hazardous air pollutant (HAP). 2005 Mar 28;156(1):181-8. doi: 10.1016/j.toxlet.2003.09.023. The available studies do not provide any evidence of genotoxicity for diethylene glycol monobutyl ether. Do not eat, drink, or smoke during work. This site needs JavaScript to work properly. Use the link below to share a full-text version of this article with your friends and colleagues. Haemolysis and degeneration of the renal tubules were observed in the kidneys, but the dose at which this occurred was not specified. Rinse skin with plenty of water or shower. There are no studies available with long-term administration of diethylene glycol monobutyl ether acetate. It is also used in printing inks when very slow drying is desired. If any worker Larese Filon F, Maina G, Adami G, Venier M, Coceani N, Bussani R, Massiccio M, Barbieri P, Spinelli P. Int Arch Occup Environ Health. In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. The application of 0.5 ml undiluted diethylene glycol monobutyl ether acetate produced slight damage to the rabbit eye after 24 hours (no other details) (Carpenter and Smyth 1946). There are no data available for the developmental toxicity of diethylene glycol monobutyl ether acetate. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, I have read and accept the Wiley Online Library Terms and Conditions of Use, Toxicology of diethylene glycol butyl ether 2. In addition, diethylene glycol accounted for 12% of the radioactivity, a non‐quantified fraction was ethylene glycol and 32% was detected in 2‐(2‐(3‐ or 4‐hydroxybutoxy)ethoxy)ethanol. DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. Epub 2017 Sep 12. Please check your email for instructions on resetting your password. Diethylene glycol monobutyl ether is suggested to be absorbed through intact skin but toxic effects only occur at very high doses. The authors did not explain this conflicting result. In vitro, diethylene glycol monobutyl ether acetate is hydrolyzed within 3 minutes to diethylene glycol monobutyl ether. There are no studies available specifically for diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether acetate was not found to have mutagenic potential in studies with Salmonella typhimurium. The rate of absorption of the test compound across Diethylene glycol monobutyl ether (DEGBE) is used: • In the preparation of blocked isocyanate systems for coil coating, electro-coating and powder coating. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. Several studies were carried out with repeated inhalation, ingestion and dermal application of diethylene glycol monobutyl ether. Diethylene glycol monobutyl ether acetate is therefore not suspected of having genotoxic effects. Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. National regulations Germany 12th Ordinance Implementing the Federal Immission Control Act - 12.BImSchV: Is not subject of the 12. The Franz method might be helpful for obtaining a grading of skin notation for hydrophilic substances: in the case of glycol ethers, it can give us precise information about permeation risk, particularly important in the evaluation of exposure. Traces of 2‐butoxy acetic acid were detected. IGL’s focus is on manufacturing ethyl / butyl glycol ethers and its acetates, which find application in the paint and coating, automotive brake fluid and electronic chemical industries. A permeation profile was obtained and steady state, lag time and permeation constant flux was calculated for each of the following solvents: ethylene glycol monoethyl ether (EGMEE), propylene glycol mono-methyl ether (PGMME); propylene glycol mono-methyl ether acetate (PGMMEac); 2-propylene glycol 1-butyl ether (2PG1BE), ethylene glycol dimethyl ether (EGDME), ethylene glycol diethyl ether (EGDEE) and diethylene glycol dimethyl ether (DEGDME). Linear Formula HOCH 2 CH 2 OCH 2 CH 2 O(CH 2) 3 CH 3. As a result of the inadequate documentation, this study cannot be included in the evaluation. Clinical toxicology of ethylene glycol monoalkyl ethers. 2017 Nov;91(11):3587-3596. doi: 10.1007/s00204-017-2046-2. After deacetylation, only a small amount of diethylene glycol monobutyl ether acetate is metabolized by alcohol dehydrogenase, while the major part is metabolized by cytochrome P450 enzymes. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. Epub 2006 Nov 10. Butyl glycol (also known as BG, 2-butoxyethanol, glycol monobutyl ether and ethylene glycol monobutyl ether, butyl cellosolve, butoxyethanol) is a clear, colourless, oily liquid with a unique sweet yet mild odour and has the formula C 6 H 14 O 2.It is a butyl ether of ethylene glycol and is miscible with water and common organic solvents. Diethylene Glycol Monobutyl Ether Acetate Market is a professional and a complete report focusing on primary and secondary drivers, market share, competitor analysis, leading segments and geographical analysis. It is a clear liquid with a very low odor and high boiling point. There are no studies available specifically for diethylene glycol monobutyl ether acetate. There are no studies available of the absorption of diethylene glycol monobutyl ether acetate via inhalation. 2004 Oct;18(5):665-71. doi: 10.1016/j.tiv.2004.03.004. In vitro studies yielded a mean permeability constant of 1.38×10‐3 cm rat skin per hour for diethylene glycol monobutyl ether acetate. When diethylene glycol butyl ether (DGBE) and diethylene glycol monobutyl ether acetate (DGBEA) were applied to the skin for 5 min then washed, most (90%) of the material was recovered. eCollection 2018. The LC50 after the exposure of rats (no other details) to diethylene glycol monobutyl ether acetate for 4 hours was 8696 ml/m3. COVID-19 is an emerging, rapidly evolving situation. Diethylene glycol monobutyl ether acetate caused slight to moderate irritation of the rabbit eye (OECD 2005). The half‐life was less than 3 minutes. “Diethylene glycol monobutyl ether” 2008). EC Index Number 203-961-6 and you may need to create a new Wiley Online Library account. A no adverse effect concentration of 14 ml/m3 (about 100 mg/m3) was obtained from the inhalation studies with rats. Eyes: Redness. In diffusion cell experiments with excised human skin, a flux of 59±36.2 µg/cm2 and hour was calculated for undiluted diethylene glycol monobutyl ether acetate. A worker who had been exposed to diethylene glycol monobutyl ether acetate and diethylene glycol monobutyl ether and had developed acute dermatitis on his hands, arms, face and neck reacted strongly to undiluted diethylene glycol monobutyl ether acetate in a patch test after 48 and 72 hours. Diethylene glycol monobutyl ether acetate is rapidly hydrolyzed to diethylene glycol monobutyl ether in vitro and in vivo (OECD 2005). There is also no information whether effects occurred after doses of 489 mg/kg body weight and day (OECD 2005). National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. After single oral doses of radioactively labelled diethylene glycol monobutyl ether acetate of 200 or 2000 mg/kg body weight, male Sprague Dawley rats exhaled about 5% of the administered radioactive dose as 14CO2. Laboured breathing, reduced activity, increased respiratory rate, anorexia, weakness, tremor and straightened posture were observed in the animals at the high doses (OECD 2005). Diethylene glycol monobutyl ether had no effect on the mating index, pregnancy incidence or male and female fertility indices after dermal application of 2000 mg/kg body weight and day for 13 weeks. NLM OBJECTIVES: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol … This product is created when ethylene oxide and n-butanol are combined. It is miscible in water, alcohol, ether, acetone, and ethylene glycol. Epub 2002 Aug 27. Studies of the ability of diethylene glycol monobutyl ether acetate to penetrate the skin or its sensitizing potential have not been carried out. 1994 May;13(5):325-35. doi: 10.1177/096032719401300508. There are no studies available of the toxic effects on reproduction of diethylene glycol monobutyl ether acetate. There are no data available for the effects of diethylene glycol monobutyl ether acetate after inhalation. DEG is a widely used solvent. Objectives: There are no studies of developmental toxicity available for diethylene glycol monobutyl ether acetate. Diethylene glycol monobutyl ether is absorbed dermally only to a small extent and is not sensitizing.  |  The course of ethylene glycol toxicity is classically divided into three broad overlapping categories of adverse health effects. After 10‐minute incubation, a plateau concentration of about 6% of the initial concentration was reached, which remained constant for about 14 minutes (OECD 2005). Diethylene glycol hexyl ether's production and use as a high boiling solvent may result in its release to the environment through various waste streams. Working off-campus? 2004). Around 5% of the radioactivity was exhaled as CO2. This corresponds to a mean absorption rate of 1.36 mg/cm2 and hour. diethylene glycol monobutyl ether ethanol diethylene glycol dimethyl ether ... provide you with protective clothing if necessary in order to protect you from skin contact with the glycol ethers marked with an "S"in the table above. The metabolites were determined in the urine. Wear safety spectacles. Would you like email updates of new search results? In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Eyes. MSDS Name: Diethylene Glycol Monobutyl Ether Synonyms: Butyl Carbitol, Glycol Ether DB, Butyl Di Glycol 2. NIH No histological changes were observed in the reproductive organs (OECD 2005). Also Peak Limitation Category I with an excursion factor of 1.5 has provisionally been established for diethylene glycol monobutyl ether acetate in analogy to diethylene glycol monobutyl ether. HAZARDS IDENTIFICATION Appearance and Odor: Clear. Results: 2003 Jun;76(5):382-6. doi: 10.1007/s00420-002-0429-y. In the high dose group, the calculated dermal penetration rate of diethylene glycol monobutyl ether acetate was 1.58 and 1.28 mg/cm2 and hour in male and female rats, respectively. Diethylene glycol monobutyl ether acetate has therefore not been designated with an “H”. A study, that was not available to the OECD in the original but only as a summary, reported slight irritation of rabbit skin after exposure to diethylene glycol monobutyl ether acetate (OECD 2005). OPINION ON DIETHYLENE GLYCOL MONOBUTYL ETHER (DEGBE) 9 chamber and the appearance of radioactivity was measured in the receptor chamber. After single oral doses of 200 or 2000 mg/kg body weight, radioactively labelled diethylene glycol monobutyl ether acetate was rapidly absorbed and metabolically degraded via diethylene glycol monobutyl ether (see Figure 1). After 1 year without exposure to diethylene glycol monobutyl ether or its acetate and with healed dermatitis, the worker did not react to diethylene glycol monobutyl ether acetate in a renewed patch test (no other details) after occlusive treatment, but reacted to the application of 0.1 ml diethylene glycol monobutyl ether acetate or diethylene glycol monobutyl ether in a test after 20 minutes of non‐occlusive treatment (Dawson et al. There are no data available for the carcinogenicity of diethylene glycol monobutyl ether acetate. Toxicol Lett. Browse other articles of this reference work: The full text of this article hosted at iucr.org is unavailable due to technical difficulties. In another study, an absorption rate of 0.035 mg/cm2 and hour was determined for human skin (OECD 2005). Damage to skin was calculated by comparing the water absorption rates of skin before and after exposure to the test compound.  |  At least the glycine conjugate can be ruled out as an impurity and must have been formed during metabolism. The dose of 3912 mg/kg body weight and day caused severe haemoglobinuria. The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents. Health Hazards: Irritating to Eyes Safety Hazard: Not classified as FLAMMABLE, but will burn HEALTH HAZARD: Skin Contact: May cause moderate irritation to skin. Diethylene glycol monobutyl ether acetate is rapidly absorbed after ingestion and eliminated mainly with the urine. A derivative compound utilizing diethylene glycol, known as diethylene glycol monobutyl ether (DEGBE), is used as a solvent in hair dyes. Percutaneous absorption of 5 glycol ethers through human skin in vitro, https://doi.org/10.1002/3527600418.mb12417e4414, http://cs3‐hq.oecd.org/scripts/hpv/Index2.asp?CASNUM=124174. BlmSchV (Hazardous Incident Ordinance) If you do not receive an email within 10 minutes, your email address may not be registered, Dry skin. Flux at steady state ranged between 0.017 +/- 0.005 and 3.435 +/- 1.897 mg/cm(2)/h and permeation rate was from 0.0192 to 1.02 x 10(-3) cm/h. Metabolites of diethylene glycol monobutyl ether acetate. In pesticide products, DEGBE acts as an inert ingredient as a deactivator for formulation before the crop emerges from the soil and as a stabilizer. There are no data available in vivo for the genotoxicity of diethylene glycol monobutyl ether acetate. In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. A MAK value of 10 ml/m3 was established for diethylene glycol monobutyl ether. Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. 2007 Jan 15;218(2):128-34. doi: 10.1016/j.taap.2006.09.019. There are no data from humans available suitable for deriving a MAK value for diethylene glycol monobutyl ether acetate. In 13‐week studies with rats exposed to diethylene glycol monobutyl ether, a NOAEL of 50 mg/kg body weight and day was obtained after oral administration and a NOAEL of 2000 mg/kg body weight and day after dermal application. Learn about our remote access options. What is Diethylene Glycol Monobutyl Ether? DEG is used as a component of multiple different products including antifreeze preparations, cosmetics, lubricants, brake fluids, wallpaper strippers, heating/cooling fuel and as a plasticizer. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. (2012) Diethylene glycol monobutyl ether [MAK Value Documentation, 1996] The MAK-Collection for Occupational Health and Safety, 10.1002/3527600418.mb11234e0007, (60-67) Bevan Ph.D C (2001) Monohydric Alcohols-C7 to C18, Aromatic, and Other Alcohols Patty's Toxicology , 10.1002/0471435139.tox078 The influence of water mixtures on the dermal absorption of glycol ethers. Ethereal. “Diethylene glycol monobutyl ether” 2008). Redness. Protective gloves. Clipboard, Search History, and several other advanced features are temporarily unavailable. Oral administration of diethylene glycol monobutyl ether in doses of 1000 mg/kg body weight and day and above over a period of 13 weeks caused increased liver weights, a reduced number of red blood cells and changes in some protein concentrations in the blood and enzyme activities in the liver of rats. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate has not been designated with “Sa” or “Sh”. Diethylene glycol monobutyl ether (DEGBE) is produced by the reaction of ethylene oxide and n-butanol with an alkalic catalyst. After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). DEG has also been inappropriately substituted in pharmaceutical preparations for nontoxic constituents, resulting in more than a dozen epidemics of human poisoning, w… Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Irritation of the gastrointestinal tract was observed at all dose levels. Packaging 1, 2.5 L in glass bottle USA.gov. DIETHYLENE GLYCOL MONOBUTYL ETHER is a ether-alcohol derivative. The odour threshold for diethylene glycol monobutyl ether acetate is <0.1 ml/m3 (Lundberg 1995). In an inadequately documented study from 1944, diethylene glycol monobutyl ether acetate was applied to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Marek EM, Koslitz S, Weiss T, Fartasch M, Schlüter G, Käfferlein HU, Brüning T. Arch Toxicol. After 24‐hour occlusive application of radioactively labelled diethylene glycol monobutyl ether acetate in doses of 2000 mg/kg body weight or of a 10% aqueous solution of 200 mg/kg body weight to the dorsal skin of 4 male or 4 female Sprague Dawley rats, up to 88% of the radioactivity was recovered within 24 hours in the urine and faeces and when the animals and cages were washed. The difference between ethylene glycol and diethylene glycol is that an ethylene glycol molecule is an individual molecule whereas diethylene glycol molecule is formed by the combination of two ethylene glycol molecules via an ether bond. No NOAEL (no observed adverse effect level) or LOAEL (lowest observed adverse effect level) was obtained in this study. There are no studies available of the clastogenicity, genotoxicity in vivo or carcinogenicity of the substance. Conclusions: TIME COURSE: After ingestion, ethylene glycol is rapidly absorbed (within 1 to 4 hours) through the stomach.Following absorption, 80% or more of ethylene glycol is chemically converted by the body into toxic compounds. Studies carried out with diethylene glycol monobutyl ether in rats did not lead to substance‐induced findings in the offspring after dermal application of up to 2000 mg/kg body weight and day or oral administration of up to 633 mg/kg body weight and day. Methods: The exposure of rats to a saturated concentration of diethylene glycol monobutyl ether acetate caused slight irritation (no other details) (OECD 2005). It can be a contaminant in consumer products; this has resulted in numerous epidemics of poisoning since the early 20th century. Untreated males were bred to … Percutaneous absorption of thirty-eight organic solvents in vitro using pig skin. 1993). In vitro studies with rat blood showed that 5 mM diethylene glycol monobutyl ether acetate was rapidly hydrolyzed to diethylene glycol monobutyl ether by esterases present in the blood. It is a colorless, practically odorless, poisonous, and hygroscopic liquid with a sweetish taste. Further unidentified metabolites were found (Boatman et al. During the first 8 hours, 59% of the low dose and 42% of the high dose were eliminated with the urine. Formation of microemulsions bred to … diethylene glycol monobutyl ether acetate used in inks... In rabbits was 5500 mg/kg body weight and day caused severe haemoglobinuria,. Propylene glycol ethers through human skin in vitro using pig skin absorption of organic. 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Mass spectrometry and its percutaneous absorption of 5 glycol ethers and glycol acetates ( Lundberg 1995 ) during first. - a commitment to public health and safety, or smoke during work used as the phase... Day was reported of rats ( no other details ) to diethylene glycol monobutyl ether acetate has therefore not carried! Long‐Term administration of diethylene glycol monobutyl ether not sensitizing ) acetic acid was a metabolite or an.! Other glycol ethers through human skin in vitro, diethylene glycol monobutyl ether has.